2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Olfactory Receptor

Olfactory Receptor

Olfactory Receptor

Olfactory receptors (ORs) are a class of G protein-coupled receptors (GPCRs) located in the nasal olfactory epithelium, belonging to class A of GPCRs with seven transmembrane helix structures, primarily responsible for detecting odor molecules. These receptors initiate a series of signal transduction events by activating G proteins and generating cAMP, leading to the production of electrical signals in olfactory neurons, which are ultimately interpreted as specific smells by the brain. Humans encode about 400 types of olfactory receptors, divided into two major subfamilies: Class I and Class II olfactory receptors.
Olfactory receptors play roles in various diseases, including olfactory loss or disorders (such as temporary olfactory loss caused by colds or rhinitis), metabolic diseases (studies have shown that some olfactory receptors regulate glucose metabolism in diabetes and obesity), and cancer (abnormal expression of olfactory receptors is related to the development of various cancers, such as prostate cancer and breast cancer). These studies not only provide a deep understanding of the functions of the olfactory system but may also offer new strategies for researching related diseases[1].

Olfactory Receptor Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-31962
    Bourgeonal
    		Agonist
    Bourgeonal is a potent agonist of hOR17-4 and acts as a strong chemoattractant in sperm behavioral assays.
    Bourgeonal
  • HY-116108
    Musk tibetene
    		Ligand
    Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line.
    Musk tibetene
  • HY-121787
    OX1a
    		Antagonist
    OX1a (OLC20) is an Orco antagonist with non-competitive activity that inhibits the activation of oxygen odor receptors (ORs). OX1a is able to reduce the activation of ORs by competitively inhibiting the effects of Orco agonists. OX1a also shows non-competitive inhibition of odor molecules, which may affect the olfactory-mediated behavior of insects. Through structural optimization, OX1a analogs have shown higher antagonistic potency, indicating that this type of compound may have application potential in a wide range of insect species.
    OX1a